https://www.beisawlab.com/news-1 daily 0.75 2026-02-27 https://www.beisawlab.com/news-1/ipp3new40msvu0293r2iz0otehe0m3 monthly 0.5 2026-02-27 https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/90ccefb3-58bd-42bf-921c-e9631513ecca/tempImageFRVGRM.jpg News - Congrats to Bailin! - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.beisawlab.com/news-1/happy-holidays-from-the-beisaw-lab monthly 0.5 2025-12-19 https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/1766152327436-2RXLXNHQW4C4LJBBPL1R/IMG_7768.jpg News - Happy holidays from the Beisaw lab! https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/1766152220504-G54FVJQ1JLZ3M08B7NU6/6c80b26e-4111-4b49-860c-2c5db9164590.JPG News - Happy holidays from the Beisaw lab! https://www.beisawlab.com/news-1/florian-accepted-to-the-medical-scientist-program monthly 0.5 2025-12-12 https://www.beisawlab.com/news-1/farewell-to-greta monthly 0.5 2025-12-10 https://www.beisawlab.com/news-1/yhumt9fskoi3iorwnzz2v7x04p9yca monthly 0.5 2025-11-20 https://www.beisawlab.com/news-1/farewell-to-lucia monthly 0.5 2025-07-07 https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/19c8af56-89e0-40d8-87d0-3bdb284bfe7c/tempImage3gP4vo.jpg News - Farewell to Lucia - We said goodbye to our BSc trainee from University of Exeter today. Thank you for your hard work and we wish you all the best in your future endeavors Lucia! And thank you for the beautiful gift! https://www.beisawlab.com/news-1/the-beisaw-lab-is-affiliated-with-the-hi-tac monthly 0.5 2025-05-21 https://www.beisawlab.com/news-1/beisaw-lab-team-building-event monthly 0.5 2025-05-21 https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/1747826510135-ZZF1VRJ6XT3NX21QRGEZ/IMG_6572.png News - Beisaw lab team building event https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/1747826680200-5O51B51VXB4FVKMTBL5C/IMG_6562.png News - Beisaw lab team building event https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/1747826681187-FUXRMBT6PBM1UXJIFR3M/IMG_6575.png News - Beisaw lab team building event https://www.beisawlab.com/news-1/opy948vswtysth7odplj0mr6q5xmwr monthly 0.5 2025-05-21 https://www.beisawlab.com/news-1/the-first-beisaw-lab-publication-is-officially-published monthly 0.5 2025-04-26 https://www.beisawlab.com/news-1/first-poster-prize-in-the-beisaw-lab monthly 0.5 2025-04-26 https://www.beisawlab.com/news-1/qwyckscjxvj3mfa3buju4dux453wt9 monthly 0.5 2024-11-28 https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/52a4577c-a21d-4377-ae80-fdacee16f114/IMG_6021.jpg News - 2nd Annual CardioAngio Science Retreat - Q&A session from the trainees - the junior group leaders giving career advice https://www.beisawlab.com/news-1/happy-birthday monthly 0.5 2024-10-02 https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/4ce7980d-4dc4-4b83-af8a-2e2fca5dc292/tempImageohOiNd.jpg News - Happy Birthday! - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.beisawlab.com/news-1/the-first-biorxiv-preprint-from-our-lab monthly 0.5 2024-03-28 https://www.beisawlab.com/news-1/first-annual-cardioangio-science-retreat monthly 0.5 2024-02-27 https://www.beisawlab.com/news-1/1amkbreeg9bhhcef79tt6uim58bwmo monthly 0.5 2023-06-02 https://www.beisawlab.com/news-1/the-lab-visits-the-christmas-markets-in-heidelberg monthly 0.5 2022-12-22 https://www.beisawlab.com/news-1/our-first-batch-of-fish-have-arrived-in-heidelberg monthly 0.5 2022-09-05 https://www.beisawlab.com/news-1/we-are-happy-to-be-a-part-of-the-crc-1550 monthly 0.5 2022-06-07 https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/407b9b9d-7314-4365-bad2-7fa435b6beee/Picture1.png News - We are happy to be a part of the CRC 1550! - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.beisawlab.com/news-1/we-are-searching-for-phdpostdocs-to-join-our-lab monthly 0.5 2022-05-06 https://www.beisawlab.com/news-1/Blog Post Title One-m8zp5 monthly 0.5 2022-03-28 https://www.beisawlab.com/home daily 1.0 2025-05-21 https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/55e58f3d-1524-480f-b6ba-801c83ea44ae/CMProt_Inverted.jpg Home - We aim to understand mechanisms of cardiomyocyte regeneration in zebrafish. Ultimately, our goal is to use this knowledge to develop therapeutic strategies to repair the diseased mammalian heart. https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/b1a5d838-9a84-46f0-b629-d1fd9069fd80/ET331a+7+dpci.jpg Home - What We Do We are interested in elucidating the molecular and cellular mechanisms of cardiac regeneration and repair. https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/ab983b16-81ca-43e2-8057-6c8cf2acdc25/LabPoster_vFish.jpg Home - Who We Are We believe that diversity, inclusion, and a supportive environment lie at the heart of successful research. https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/fc4b516a-8168-49a9-8e23-1bd13a61a860/JunbFosl1transf+TNI488+Junb568+zoom-Orthogonal+Projection-09-1.czi+%28RGB%29.jpg Home - What have we been up to? Check out our lab news. https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/1645711644311-934ZHLM9K1UNU329E16C/unsplash-image-McX3XuJRsUM.jpg Home - Our Work https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/b91b4d45-6150-4305-a427-6c998223b8b2/HLA_HDMA_logo.png https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/f034402c-d418-4b34-ad43-3fb4e7fc4f14/Picture1.png https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/57c09b30-c17d-4e9f-8118-298bd3a648ff/DFG_logo.png https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/64123ff3-ec24-43ab-b75a-528eebab434c/Logo+HI+TAC.jpg https://www.beisawlab.com/team-2 daily 0.75 2026-02-13 https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/d7798036-a313-4238-a837-f3c75e42d587/Feb2026_2.jpeg Team - Make it stand out Beisaw Lab group photo - February 2026 https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/73edb0ad-78e8-4bf3-991c-a5693a4b27de/AB2.jpg Team - GROUP LEADER PhD - Max Planck Institute for Molecular Genetics, Berlin, Germany (with Prof. Bernhard Herrmann and Dr. Phillip Grote) Postdoc - Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany (with Prof. Didier Stainier) Google Scholar ORCID https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/f3c1c6b1-aebb-47ec-ac7d-dc07de70ec4b/Constanty_Florian_3.jpg Team - POSTDOCTORAL FELLOW Florian joined our lab in January 2023 and was the recipient of an Inter-Institutional Postdoctoral fellowship from Health and Life Science Alliance Heidelberg/Mannheim. He is currently investigating the cardiomyocyte regenerative niche. https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/c79951cf-ba6e-438c-8d4a-16f6ffa0f5da/Alina.jpeg Team - PHD STUDENT Alina successfully acquired a DAAD fellowship and joined our lab in October 2023 to pursue her doctoral work. Alina is currently optimizing in vitro systems to investigate cellular and molecular mechanisms of cardiomyocyte invasion. https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/372b6049-4e46-4171-815b-e9a373c114aa/SrishtiLab+photo.jpg Team - PHD STUDENT Srishti joined our lab in November 2022 and is elucidating the role of AP-1 transcription factors in regulating the chromatin landscape in response to cardiac injury. https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/65425bc8-30fd-46b5-b5ad-4b91cbb16a98/122.jpg Team - PHD STUDENT Bailin joined our lab in November 2022 and is investigating CM-intrinsic mechanisms of CM invasion and the importance of cell:cell interactions at the border zone of regenerating zebrafish hearts. https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/7367347b-68dd-49f0-a289-cda3ebdfa79a/Bakali_personalphoto.jpg Team - RESEARCH TECHNICIAN Vasiliki joined our lab in March 2025 and is contributing to several lines of research in the lab to increase our understanding of the molecular and cellular mechanisms underlying cardiac regeneration. https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/d0bcc364-4744-4bcd-8fc6-8ca26ae52eba/Louisa.jpeg Team - BSc TRAINEE Louisa joined us in 2025 for a practical training year as part of her BSc program at the University of Exeter (UK). She is currently working together with Florian to understand the cardiac regenerative niche. https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/b3736930-e3d8-40b9-8e00-038834b6d3d8/LaraSz.jpg Team - STUDENT ASSISTANT Lara is currently a BSc student at UniHD and is working together with Bailin to investigate how cardiomyocytes replace fibrotic wound tissue during regeneration. https://www.beisawlab.com/join-us daily 0.75 2025-02-26 https://www.beisawlab.com/contact-us daily 0.75 2025-11-20 https://www.beisawlab.com/privacy-policy daily 0.75 2022-03-28 https://www.beisawlab.com/research-1 daily 0.75 2022-02-21 https://www.beisawlab.com/research-1/project-two-9aw8j monthly 0.5 2022-02-10 https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/fc7178f5-15c5-4bc0-a831-bd891c05795a/CM_Endo.jpg Research - Intercellular communication in cardiac regeneration - Intercellular communication in cardiac regeneration Protruding cardiomyocytes (magenta) at the border zone surrounded by endocardial cells (green). https://www.beisawlab.com/research-1/project-one-4pkfp monthly 0.5 2022-02-16 https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/08974f30-848b-4729-9df2-f19e7815a19e/Fig1_TF.jpg Research - Transcriptional and epigenetic networks regulating cardiac regeneration Presence of AP-1 motifs in accessible chromatin in regenerating zebrafish cardiomyocytes. https://www.beisawlab.com/publications daily 0.75 2025-05-21 https://www.beisawlab.com/publications/new-portfolio-item-1 monthly 0.5 2025-05-21 https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/00ffe786-a0a3-4651-b5a3-e67c1cc525cf/Figure1.png Publications - Cardiac regeneration: Unraveling the complex network of intercellular crosstalk - Cardiac regeneration: Unraveling the complex network of intercellular crosstalk Here, we review current literature regarding how intercellular crosstalk and cell:ECM interactions regulate the process of cardiac regeneration. We focus on different cell types in the heart, including cardiomyocytes, fibroblasts, immune cells, endothelial and endocardial cells. Furthermore, we provide a short overview of recently established experimental techniques to understand intercellular crosstalk in vivo and end by providing some insight into interorgan communication in the context of cardiac regeneration. This review is part of the special issue “Recent Advances in Cardiovascular Biology”. https://www.beisawlab.com/publications/new-portfolio-item monthly 0.5 2024-03-25 https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/75de6251-3038-400f-980b-6b9f5fdfd8b4/Screenshot+2025-04-26+at+10.04.52.png Publications - CM protrusion and invasion in zebrafish heart regeneration - Border-zone cardiomyocytes and macrophages regulate extracellular matrix remodeling to promote cardiomyocyte protrusion during cardiac regeneration. We provide a comprehensive characterization of CM protrusion and invasion during zebrafish cardiac regeneration using histological and time-lapse imaging approaches. Further, using genetic and clodronate ablation models, we provide evidence that macrophage presence at the border zone of regenerating hearts is essential for ECM remodeling and subsequent CM invasion. We show that Mmp14b plays an important role in macrophage presence and ECM remodeling at the border zone and subsequent CM invasion. Lastly, we also show that CM-specific mmp14b OE is sufficient to promote CM invasion in vivo. https://www.beisawlab.com/publications/project-one-cpl8g monthly 0.5 2022-03-03 https://images.squarespace-cdn.com/content/v1/6202d337d9ce5a7ba6b85db9/cc1b76d6-3027-4359-8a64-5d66e774847e/circresaha.119.316167.fig08.jpg Publications - AP-1: an essential regulator of zebrafish cardiomyocyte regeneration - AP-1 TFs are essential regulators of zebrafish cardiomyocyte regeneration We show here that AP-1 transcription factor genes are upregulated in border zone cardiomyocytes (CMs) following cryoinjury. Furthermore, using CM-specific dominant-negative approaches, we found that AP-1 contributes to chromatin accessibility changes in regenerating CMs and that AP-1 is essential for multiple aspects of CM regeneration, including dedifferentiation, proliferation, sarcomere disassembly, and invasion of the injured area. Notably, we found that the AP-1 response largely differs in regenerative zebrafish versus nonregenerative mouse CMs and that overexpression of Junb and Fosl1 in mammalian CMs can promote hallmarks of CM regeneration in vitro.