Cardiac regeneration: Unraveling the complex network of intercellular crosstalk
Here, we review current literature regarding how intercellular crosstalk and cell:ECM interactions regulate the process of cardiac regeneration. We focus on different cell types in the heart, including cardiomyocytes, fibroblasts, immune cells, endothelial and endocardial cells. Furthermore, we provide a short overview of recently established experimental techniques to understand intercellular crosstalk in vivo and end by providing some insight into interorgan communication in the context of cardiac regeneration.
This review is part of the special issue “Recent Advances in Cardiovascular Biology”.
Wu B, Constanty F, Beisaw A#. Cardiac regeneration: unraveling the complex network of intercellular crosstalk. Seminars in Cell and Developmental Biology. 2025; 171. doi:10.1016/j-semcdb.2025.103619. *contributed equally, #corresponding author